Program

Tuesday June 04	Conseil Régional des Hauts-de-France, Av. du Président Hoover, Lille
14:00 – 16:00	Registration SialoGlyco 2024 – Coffee
16:00 – 16:30	Welcome for the SialoGlyco 2024
16:30 – 18:30	Opening lectures
16:30 – 17:00	Philippe Delannoy (Lille, France) My sweet life in cancer sialoglycobiology.
17:00 – 17:30	Chihiro Sato (Nagoya, Japan) Is there a polySia-synthesizing enzyme other than ST8SIA2 and ST8SIA4?
17:30 – 18:00	Mark Von-Itzstein (Gold Coast, Australia) Targeting clinically significant sialic acid-recognizing viruses.
18:30 -	Welcome Party

Wednesday June 05	Conseil Régional des Hauts-de-France, Av. du Président Hoover, Lille
Session 1	Genomics and informatics – Chairs : Anne Harduin-Lepers & Christian Bull
9:00 – 9:30	Daniel Bojar Sialic Acid's Symphony: Composing Function Through Sequence.
9:30 – 9:50	Hiromu Takematsu Utilization of transcriptomic analyses, CIRES (correlation index-based responsible enzyme gene screening) to understand sialyl-Lewis X epitope expression.
9:50 – 10:10	Huei-Syuan Jiang Comprehensive Identification of Genes Contributing to the Expression of Siglec-15 Ligands on Osteoclast Precursors by Genome-wide Knockout Screening.
10:10 – 10:30	Sylvain Lehoux Sponsor talk - Lectenz - A novel class of high-specificity affinity reagents for detection and purification of sialo-glycoconjugates
10:30 - 11:00	Coffee break
Session 2	New technologies- Chairs: Daniel Bojar & Kay Hooi Khoo
11:00 - 11:30	Christian Bull Biosynthesis and applications of human sialoglycoproteins.
11:30 - 11:50	Warren Wakarchuk Corynebacterium glutamicum as a Recombinant Platform for the Expression of Bacterial and Eukaryotic Sialyltransferases.
11:50 - 12:10	Daniël Hornikx Light-controlled spatiotemporal desialylation with a photoactivatable sialyltransferase inhibitor.
12:10 - 12:30	Pedro E. Guerrero Barrado Targeting hypersialylation in pancreatic ductal adenocarcinoma models generated with microfluidic devices reverses its malignant phenotype.
12:30 - 13:00	Poster Talks (1 min/poster)
13:00 - 14:00	Lunch
14:00 - 15:00	Poster session 1
Session 3	Chemistry - Chair: Josef Voglmeir & Christophe Biot
15:00 – 15:30	Hiromune Ando Stereo-controlled a-glycosidations of sialic acid and Kdo using macrobicyclic glycosyl donors.
15:30 – 15:50	Venetia Psomiadou Efficient Synthesis of Siglec Ligands: Five-Step Journey from Sialyllactose Precursors.
15:50 – 16:10	Fuming Zhang Synthesis multivalent sialyllactose-conjugated PAMAM dendrimers: Binding to SARS-CoV-2 spike protein and influenza hemagglutinin.
16:10 – 16:30	Naoko Komura First total synthesis of ganglioside SJG-2 isolated from Stichopus japonicus.
16:30 - 17:00	Coffee break
Session 4	Diversity and Evolution - Chair: Yann Guérardel & Michael Jennings
17:00 – 17:30	Josef Voglmeir Divergence in Sialic Acid Biosynthesis in Vertebrates and Invertebrates.
17:30 – 17:50	Ken Kitajima Comparative study of substrate specificity of the deuterostome CMP-sialic acid synthetases.
18:50 – 18:10	Martin Pabst Beyond diseases: sialylated surface layer proteins in ammonium-oxidizing bacteria.
18:10 – 18:30	Moritz Rahm Sialic acid derivates derived from reduction and oxidation reactions can be found in human.

Thursday June 06	Conseil Régional des Hauts-de-France, Av. du Président Hoover, Lille
Session 5	Metabolic Enzymes - Chair: Philippe Delannoy & Chihiro Sato
9:00 – 9:30	Anne Harduin-Lepers Molecular and functional evolution of vertebrate sialyltransferases.
9:30 – 9:50	Yasuhiko Kizuka LacdiNAc synthase B4GALNT3 has a possible lectin domain and blocks N-glycan capping.
9:50 – 10:10	Martina Mühlenhoff Identification of a second catalytic center in the sialate O-acetyltransferase CASD1.
10:10 – 10:30	Takahiro Nakagawa The effect of metal ions on the activity of Kdn-sialidase from Sphingobacterium sp. strain HMA12.
10:30 - 11:00	Coffee break
Session 6	Cancer - Chair: Tony Lefebvre & Ken Kitajima
11:00 – 11:20	Celso A. Reis The Diversity And Functionality Of The Cancer Glycome: The Major Role Of Sialylation In Oncogenic Processes And Clinical Implications.
11:20 – 11:40	Nurmaa Dashzeveg Chemotherapy induces the loss of sialic acid that promotes metastatic seeding of circulating tumor cells in breast cancer.
11:40 – 12:00	Sandra van Vliet Site-specific reprogramming of the tumor-immune microenvironment by sialic acids.
12:00 – 12:20	Takashi Angata Siglec-15 facilitates lung metastasis of breast cancer in a mouse model
12:20 – 12:40	Jodie Scache Application of sialic acid metabolic glycoengineering to decipher the regulation of glycoprotein trafficking by O-GlcNAcylation in human colon cells
12:40 – 13:00	Benoit Darblade Sponsor Talk Elicityl
13:00 - 14:00	Lunch
Session 7	Infection - Chair: Yannick Rossez & Mark von Itzstein
14:00 - 14:30	Michael Jennings The essential Plasmodium falciparum malaria protein PFCyRPA targets sialic acid glycans to invade erythrocytes.
14:30 - 14:50	Gael Martin Understanding cell-type specific selection pressure mechanism for Enterovirus A71: The key to the development of relevant infection models and novel antiviral compounds
14:50 - 15:10	Patrice Guillon Insights into the human metapneumovirus glycointeractome: a novel avenue for antiviral drug design
15:10 - 15:30	Sumati Bhatia Leveraging sialylated architectures to combat viral infections
15:30 - 15:50	Robert P. de Vries Circulating highly pathogenic H5Nx influenza A viruses bind promiscuously to avian-type mucin-like O-glycans
16:00 - 18:30	Social Program: Fine Art Museum of Lille, Musée de la Piscine Roubaix, Guided tour of Lille
19:30 -	Meeting Banquet at L’Hermitage Gantois 224 Rue Pierre Mauroy, 59000 Lille - https://www.hotelhermitagegantois.com/ Founded in 1462, l’Hermitage Gantois was a hospice until 1995. It has always welcomed the elderly and the sick of the Lille region, the hospice building being a witness to this crossing of the centuries. Completely restored, it has been one of the most beautiful 5-star hotels in Lille since 2003.

Friday June 07	Conseil Régional des Hauts-de-France, Av. du Président Hoover, Lille
Session 8	Glycomics - Chair: Yann Guerardel & Kazuki Nakajima
9:00 – 9:30	Kay Hooi Khoo Identification of 6-sulfo- sialylated Gal and LacNAc glycotopes by mass spectrometry-based sulfoglycomic analysis.
9:30 – 9:50	Manfred Wuhrer Low Levels of Global α2,3-Sialylation of the Plasma N-Glycome Mark Fibrosis in Metabolic-Dysfunction Associated Steatotic Liver Disease.
9:50 – 10:10	Noortje de Haan Cellular Glycomics by Mass Spectrometry to Study Sialic Acid Presentation, Localization and Regulation.
10:10 – 10:30	Jitske van Ede Profiling the molecular diversity of activated nonulosonic acids in microbes.
10:30 - 11:00	Coffee break
Session 9	Young Researchers - Chair: Sophie Groux-Degroote & Daniel Bojar
11:00 – 11:15	Clément Delannoy Sweet Symbiosis : Anemonefish use sialic acids to avoid giant sea anemone stinging.
11:15 – 11:30	Frania J. Zúñiga-Bañuelos Discovering Rare Sialylated N-glycans Holding O-Acetylation or Sulfation within the Site-Specific N-glycosylation of Human Serum IgA.
11:30 – 11:45	Mengying Liu Exploring H3N2 Influenza A Virus Receptor Specificity through Binding and Entry in a Cell-Based Sialoglycan Library.
11:45 – 12:00	Rita Adubeiro Lourenço Aberrant sialylation as cancer biomarkers and as possible therapeutic target.
12:00 – 12:15	Elodie Evangélaire Structural characterization of a pseudaminic-rhamnosyl disaccharide bounds to CgeA protein on the spore surface of Bacillus subtilis.
12:15 – 12:30	Sebastian Andrei Investigating the role of sialic acids in Candidatus Accumulibacter with metabolic oligosaccharide engineering.
12:30 – 12:45	Sjanie Huang Human N-acetylneuraminate lyase acts as gatekeeper for the right sialic acid.
12:45 – 13:00	Zoé Durin SPCA1 deficiency, that leads to a dramatic skin disease, affects sialylation rates by influencing the Ca2+-dependent intracellular traffic.
13:00 - 14:00	Lunch
14:00 - 15:00	Session Poster 2
Session 10	Neurobiology - Chair: Chihiro Sato & Kenji Uchimura
15:00 - 15:30	Herbert Hildebrandt Polysialic acid-Siglec immune checkpoints in glioblastoma, myelin repair and aging.
15:30 - 15:50	Kenji Uchimura Analysis of 5D4-reactive sialylated and sulfated glycan elicited in microglia in Parkinson’s disease mouse models
15:50 - 16:10	Masaya Hane ELISA-based novel analysis method for the interaction between polysialic acid and small molecule compounds
16:10 - 16:30	Hauke Thiesler Release of polysialylated proteins into the microenvironment of an intracranial rat glioma model
16:30 - 17:00	Coffee break
Session 11	Development and immunity- Chair: Herbert Hildebrandt & Ikram El Yazidi-Belkoura
17:00 - 17:20	Anja Münster-Kühnel Role of Polysialic in Kidney Development
17:20 - 17:40	Lisa Willis GPR15 Is A Novel Polysialylated Protein That Is Required For T Cell Migration Towards GPR15L
17:40 - 18:00	Lisa Isernhagen Rapid Changes in Sialylated Milk Oligosaccharides in Holstein Cows During Early Lactation
18:00 - 18:20	Takeshi Tsubata Roles of interaction of CD22 (Siglec-2) with its α2,6-sialylated cis-ligands in B lymphocytes.
18:20 -	Closing Remark